Single-dose azithromycin for childhood cholera

Single-dose azithromycin for the treatment of cholera in adults.

BACKGROUND Single-dose azithromycin is effective in the treatment of severe cholera in children, but its effectiveness in adults has not been evaluated. METHODS We conducted a double-blind, randomized trial comparing the equivalence of azithromycin and ciprofloxacin (each given in a single 1-g dose of two 500-mg tablets) among 195 men with severe cholera caused by Vibrio cholerae O1 or O139. ...

Single-dose azithromycin for trachoma.

Single dose azithromycin versus ciprofloxacin for cholera in children: a randomized controlled trial.

OBJECTIVE To compare the clinical and bacteriological success of single dose treatment with azithromycin and ciprofloxacin in children with cholera. DESIGN Randomized, open labelled, clinical controlled trial. SETTING Tertiary care hospital. PARTICIPANTS 180 children between 2-12 years, having watery diarrhea for < or = 24 hr and severe dehydration, who tested positive for Vibrio cholerae...

Single dose tetracycline in cholera

A randomised clinical trial was carried out to explore the efficacy of single dose tetracycline therapy in cholera. One hundred and eighteen adult patients were assigned to receive either tetracycline in a single 1 g, or a single 2 g dose, or tetracycline 500 mg every six hours four times, or no antibiotics as controls. The means of total liquid stool volumes after treatment were lower in the s...

Mass treatment with single-dose azithromycin for trachoma.

BACKGROUND Trachoma, caused by repeated ocular infection with Chlamydia trachomatis, is an important cause of blindness. Current recommended dosing intervals for mass azithromycin treatment for trachoma are based on a mathematical model. METHODS We collected conjunctival swabs for quantitative polymerase-chain-reaction assay of C. trachomatis before and 2, 6, 12, 18, and 24 months after mass ...